19. Annie Clark—St. Vincent
St. Vincent's frontwoman Annie Clark started playing guitar when she was 12 years old. She honed her skills in the high school jazz band and continued studying for three years at Berklee College of Music before dropping out. She's got the technical skills, but that's not what makes her such a special talent. For Annie, the guitar is just a tool she uses to express herself, and her creative vision is what sets her apart. What Annie does best is a mix between whimsical and abrasive—songs like "Dilettante" have Annie transforming her guitar into a peace-disturbing weapon, giving an interesting edge to counter those sweet vocals of hers.